Stability of selected chlorinated thiazide diuretics
نویسندگان
چکیده
منابع مشابه
Thiazide diuretics in hypertension
Authors: Ferreira R. The use of diuretics (and beta-blockers) to treat hypertension has known a dramatic decline since the early 1980’s through to the early 1990s with the introduction of ACE-inhibitors and calcium channel blockers. However, thiazide diuretics are still a first line option to treat arterial hypertension, due to their efficacy and cost-effectiveness profile. We have presented ma...
متن کاملComparison of thiazide‐like diuretics versus thiazide‐type diuretics: a meta‐analysis
Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide-type diuretics hydrochlorothiazide and thiazide-like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the exis...
متن کاملPrimary hyperparathyroidism and thiazide diuretics.
Six patients receiving thiazide diuretics were referred for evaluation of mild to moderate hypercalcaemia (serum calcium 2.65-2.98 mmol/l). All patients were considered to be suffering from primary hyperparathyroidism. Withdrawal of the diuretic was followed by a reduction in the serum calcium, one patient becoming normocalcaemia. The mechanisms responsible for these changes are discussed. In h...
متن کاملDiuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics.
INTRODUCTION Thiazides and thiazide-like diuretics inhibit the electroneutral Na(+)-Cl(-) cotransporter located on the apical membrane of the early segment of the distal convoluted tubule. They have been widely prescribed over 60 years in the treatment of hypertension and various edematous states. AREAS COVERED Thiazide diuretics reduce blood pressure (BP), although the mechanisms by which th...
متن کاملMechanism of antihypertensive effect of thiazide diuretics.
Hemodynamic studies were carried out before and during 8 weeks of treatment with hydrochlorothiazide 50 mg. twice daily in 11 hypertensive patients. Forty-eight hours after beginning treatment there was a significant reduction in blood pressure, cardiac output, plasma volume, and extracellular fluid volume (thiocyanate space) while total peripheral resistance increased. After 6 and 8 weeks of t...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical and Biomedical Analysis
سال: 2009
ISSN: 0731-7085
DOI: 10.1016/j.jpba.2008.11.001